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Facts About...


Brand Names


Reason for taking this medicine

Pyrazinamide (PZA) is used to treat tuberculosis (TB). It is used with other TB medicines.

How to take this medicine

  • It is very important that you take pyrazinamide as prescribed
  • If you think you might be pregnant, or you are breastfeeding, tell your doctor/health care provider before starting pyrazinamide
  • If you miss a dose, take it as soon as possible, but never take two doses at one time
  • You can take pyrazinamide with or without food
  • Do not drink alcohol while taking pyrazinamide
  • Avoid the sun as pyrazinamide can make your skin more sensitive to the sun
  • Do not store pyrazinamide near sun, heat, or moisture
  • While you are on pyrazinamide, your doctor/health care provider will ask you to have regular blood tests to monitor your liver.


  • Tell your doctor/health care provider and pharmacist about any drug allergies before starting pyrazinamide
  • Tell your doctor/health care provider if you have diabetes, gout, liver or kidney disease, or drink alcohol
  • Always tell your doctor/health care provider and pharmacist if you are taking other medicines or vitamins
  • Flushing and/or itching of the face and scalp, watery eyes, usually 2-3 hours after taking pyrazinamide. An anti-allergy medication can be taken to treat this.

While most people can take pyrazinamide with no problem, pyrazinamide may have some side effects and affect your liver. This is called hepatitis. Stop taking your TB medicines, call your doctor/health care provider right away, if you have any of the following symptoms:

  • Yellowing eyes and/or skin
  • Sever loss of appetite
  • Severe nausea and vomiting
  • Stomach pain
  • Fever, chills
  • Very dark urine
  • Skin rash, severe itching or hives
  • Pain or swelling in the joints
  • Feeling very tired

August 2016