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Facts About...


Brand Names

Rifadin, Rofact

Reason for taking this medicine

Rifampin is used alone or with other medicines to treat or prevent tuberculosis (TB).

How to Take This Medicine

  • It is very important that you take rifampin as prescribed
  • If you think you might be pregnant, or you are breastfeeding, tell your doctor/health care provider before starting rifampin
  • Birth control pills may not work as well when taking rifampin. Other forms of birth control should be used (e.g., condoms)
  • If you miss a dose, take it as soon as you can but never take two doses at one time
  • It is best to take rifampin on an empty stomach (one hour before a meal or 2 hours after)
  • If rifampin upsets your stomach, try taking it with a small amount of food.
  • Rifampin can affect your other medicines; always tell your doctor/health care provider and pharmacist if you are taking other medicine or vitamins
  • Avoid alcohol while taking rifampin
  • Do not store rifampin in areas where there is direct sunlight, heat and/or moisture
  • While you are on rifampin, your doctor/health care provider will ask you to have regular blood tests to monitor your liver


  • Tell your doctor/health care provider and pharmacist about drug allergies before starting rifampin
  • Tell your doctor/health care provider if you have ever had liver disease
  • Urine, stools, saliva, phlegm, sweat, and tears can turn reddish-orange-brown in colour while taking rifampin. This side effect is normal.
  • Soft contact lenses may get stained while on this medication and should not be worn.

While most people can take rifampin with no problem, rifampin may cause some side effects. Tell your doctor/health care provider if you have:

  • Headache, drowsiness, dizziness, poor concentration, confusion
  • Flushing and/or itching of the skin with or without a rash, usually on the face and scalp, and/or redness/watering of the eyes. This reaction usually occurs 2-3 hours after taking rifampin. An anti-allergy pill can be taken to treat this

Rifampin can affect your liver. This is called hepatitis. Stop taking your TB medicines, and call your doctor/health care provider right away, if you have the following symptoms:

  • Yellowing of eyes and skin
  • Bleeding or bruising
  • Loss of appetite
  • Severe nausea and vomiting
  • Severe stomach cramps or pain
  • Fever, chills
  • Very dark urine
  • Feeling very tired

August 2016